Recently, Professor Sun Fei's research group and Professor Wang Jun's research group of School of Life Sciences and Medical Center, University of Science and Technology of China, worked together to find that the photothermal effect of nanomaterials can effectively and safely control male mammals, thereby reducing animal The purpose of reproductive ability. The research results were published online in the "Nano Express" published in May.
Photothermal materials represented by nano-sized gold nanorods can effectively convert light energy into heat energy under the irradiation of near-infrared light. Since the beginning of this century, they have been widely used in nanobiology, especially tumor light In heat therapy. Photothermal therapy relies on heat to kill tumor cells, combined with the accurate space control performance of infrared lasers, it can maximize the tumor suppression effect while avoiding the toxic and side effects of traditional treatment methods.
The new research of the Chinese University of Science and Technology breaks through the application field of nano-photothermal materials. First, it proposes a research foundation based on the testis tissue that is easily damaged by high temperature, and uses nanomaterial photothermal therapy to achieve contraception in male animals. Through in situ injection of gold nanorods, combined with near-infrared light irradiation, under the conditions of reasonable adjustment of injection dose and irradiation intensity and time, the reproductive ability of mice can be temporarily restored or permanently destroyed for a long time, but it does not affect Sex hormone levels in mice. This method can also effectively avoid the destruction of other tissues and organs of mice by traditional hyperthermia, and combines the advantages of safety, effectiveness, low cost, and easy operation.
With the development of urbanization, many stray animals have been produced in human living areas. In megacities, the number of stray cats and dogs often exceeds one million. Stray animals have a short reproductive cycle, a large number, fast speed, and long-term survival in harsh environments, which is an important way for bacteria and viruses to spread. Sterilization and immunization are the key to solving the social problem of stray animals. However, in addition to traditional castration methods, currently non-invasive treatments such as chemical castration are still in the research and development stage, and the only two drugs marketed in Europe are limited to animals of a specific age and type.
This research is expected to realize a new male contraceptive method, which has good application prospects and provides an important prerequisite for the next step of developing new male contraceptive technology. It has applied for a national invention patent. At the same time, the study further confirmed that the local high temperature environment of the testes can affect reproduction.
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